Design and operational control of an AGV system

In this paper we first deal with the design and operational control of Automated Guided Vehicle (AGV) systems, starting from the literature on these topics. Three main issues emerge: track layout, the number of AGVs required and operational transportation control. An hierarchical queueing network approach to determine the number of AGVs is decribed. Also basic concepts are presented for the transportation control of both a job-shop and a flow-shop. Next we report on the results of a case study, in which track layout and transportation control are the main issues. Finally we suggest some topics for further research

A practical solution to a newspaper distribution problem

In this paper the problem of distributing newspapers is treated. After a general introduction on this topic, a mathematical model for a hierarchical distribution system is given explicitly and a heuristic consisting of several solution techniques is described. Furthermore, some results of the application of this heuristic in a study performed for a Dutch regional newspaper are presented and discussed. There is also an indication as to how the approach could be improved

Optimal linear decision rules for a work force smoothing model with seasonal demand

This paper gives a procevure for the determination of the optimal linear control for a production-inventory system in steady-state with non-linear costs per period and normally distributed seasonal demand. In an example this control policy is compared with other policies

Warehouse design and control: framework and literature review

In this paper we present a reference framework and a classification of warehouse design and control problems. Based on this framework, we review the existing literature on warehousing systems and indicate important gaps. In particular, we emphasize the need for design oriented studies, as opposed to the strong analysis oriented research on isolated subproblems that seems to be dominant in the current literature

Strict selection alone of patients undergoing liver transplantation for hilar cholangiocarcinoma is associated with improved survival

Liver transplantation for hilar cholangiocarcinoma (hCCA) has regained attention since the Mayo Clinic reported their favorable results with the use of a neo-adjuvant chemoradiation protocol. However, debate remains whether the success of the protocol should be attributed to the neo-adjuvant therapy or to the strict selection criteria that are being applied. The aim of this study was to investigate the value of patient selection alone on the outcome of liver transplantation for hCCA. In this retrospective study, patients that were transplanted for hCCA between1990 and 2010 in Europe were identified using the European Liver Transplant Registry (ELTR). Twenty-one centers reported 173 patients (69%) of a total of 249 patients in the ELTR. Twenty-six patients were wrongly coded, resulting in a study group of 147 patients. We identified 28 patients (19%) who met the strict selection criteria of the Mayo Clinic protocol, but had not undergone neo-adjuvant chemoradiation therapy. Five-year survival in this subgroup was 59%, which is comparable to patients with pretreatment pathological confirmed hCCA that were transplanted after completion of the chemoradiation protocol at the Mayo Clinic. In conclusion, although the results should be cautiously interpreted, this study suggests that with strict selection alone, improved survival after transplantation can be achieved, approaching the Mayo Clinic experience

Padrão geográfico de diversidade genética em populações naturais de Pau-rosa (Aniba rosaeodora), na Amazônia Central

Rosewood (Aniba rosaeodora Ducke, Lauraceae) is an Amazonian evergreen tree and a source of the purest linalool, the main component of its essential oil, which is very valuable in the international perfumery market. After decades of over-exploitation it is currently considered as threatened. We evaluated the genetic diversity and its distribution in four populations in Central Amazonia. Thirty-five reliable RAPD markers were generated, of which 32 were polymorphic (91.4%). Variation was higher within the populations (76.5%; p < 0.0001) and geographic distribution contributed to population differentiation (23.4%; p < 0.0001). The Amazon River had a small influence on gene flow (3.3%; p < 0.0001), but we identified evidence of gene flow across the river. There were significant differences in marker frequencies (p < 0.05), in agreement with the low gene flow (Nm = 2.02). The correlation between genetic distance and gene flow was - 0.95 (p = 0.06) and between geographic distance and gene flow was -0.78 (p = 0.12). There was a geographic cline of variability across an East-West axis, influenced as well by the Amazon River, suggesting the river could be a barrier to gene flow. Although threatened, these Rosewood populations retain high diversity, with the highest levels in the Manaus population, which has been protected for over 42 years in a Reserve.O Pau-rosa (Aniba rosaeodora Ducke, Lauraceae) é uma árvore amazônica fonte do mais puro linalol, o qual é o principal componente do seu óleo essencial e muito valioso no mercado internacional de perfumaria. Após várias décadas de intensa exploração, a espécie foi levada à categoria de ameaçada de extinção. Quatro populações naturais distribuídas na bacia Amazônia Central foram avaliadas quanto ao nível e a distribuição da diversidade genética. Trinta e cinco marcadores RAPD reprodutíveis foram gerados, dos quais 32 foram polimórficos (91,4%). A diversidade foi maior dentro das populações (76,5%; p < 0,0001) e a distribuição geográfica contribuiu para a diferenciação entre as populações (23,4%; p < 0,0001). A AMOVA indicou que pode haver uma influência parcial do Rio Amazonas no fluxo gênico (3,3%; p < 0,0001), mas foram identificadas evidências de fluxo gênico atravessando o rio. Houve diferenças significativas nas freqüências dos marcadores (p < 0,05) e o fluxo gênico estimado foi relativamente baixo (Nm = 2,02). A correlação entre a distância genética e o fluxo gênico foi de - 0,95 (p = 0,06) e para a distância geográfica e o fluxo gênico foi de - 0,78 (p = 0,12). Houve um padrão geográfico de variabilidade ao longo do eixo Leste - Oeste, influenciado também pelo Rio Amazonas, o que sugere que o rio poderia funcionar como uma barreira para o fluxo gênico. Apesar de ameaçadas, estas populações de Pau-rosa possuem alta diversidade, com o maior valor na população de Manaus, que vem sendo protegida por 42 anos em uma reserva

Logitrace. A Decision Support System for Warehouse Design

Im Beitrag wird das gemeinsam vom Dortmunder Fraunhofer Institut Materialfluss und Logistik mit der Universität Twente entwickelte Planungswerkzeug LOGITRACE vorgestellt. Dieses ist ein modular aufgebautes Auswahlsystem für Kommissioniersysteme, bei denen der Schwerpunkt auf der Auswahl und der kapazitäts- und leistungsmäßigen Bestimmung des Lagersystems sowie der dazugehörigen Codehilfsmittel liegt. Ergänzend dazu ist ein Daten-Analyse-System zur Auswertung von Auftragsdaten entwickelt worden, mit dem die für die Dimensionierung notwendigen Parameter gewonnen werden können

Warehouse design and control : a framework and a literature review

In this paper we present a reference framework and a classification of warehouse design and control problems. Based on this framework, we review the existing literature on warehousing systems and indicate important gaps. In particular, we emphasize the need for design oriented studies, as opposed to the strong analysis oriented research on isolated subproblems that seems to be dominant in the current literature